Relationship of the Molecular Size and Charge Density of Polyoxometalates to Their anti-gp120-CD4-binding Activity-Reference-Cited by-同舟云学术

Relationship of the Molecular Size and Charge Density of Polyoxometalates to Their anti-gp120-CD4-binding Activity

Published:1994-12 Issue:6 Volume:5 Page:410-414
ISSN:2040-2066
Container-title:Antiviral Chemistry and Chemotherapy
language:en
Short-container-title:Antivir Chem Chemother

Author:

Judd D. A.¹,Schinazi R. F.²³,Hill C. L.¹

Affiliation:

1. Department of Chemistry, Emory University, Atlanta, GA 30322, USA

2. Department of Pediatrics, Emory University, Atlanta, GA 30322, USA

3. Veterans Affairs Medical Centre, Decatur, GA 30033, USA

Abstract

The ability of several classes of polyoxometalates to inhibit the interaction between HIV-1 gp120 and CD4 was assessed. No clear relationship was found between binding inhibition and the negative charge density on the anion portion of the polyoxometalate. However, a weak correlation was found with molecular size. There was a molecular weight threshold of 3800 g mol-1 above which no significant increase in potency was gained; the binding inhibition was nearly quantitative above this molecular weight.

Publisher

SAGE Publications

Link

http://journals.sagepub.com/doi/pdf/10.1177/095632029400500609

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