In vitro Inhibitory Effects of Combinations of anti-Influenza Agents-Reference-Cited by-同舟云学术

In vitro Inhibitory Effects of Combinations of anti-Influenza Agents

Published:1995-04 Issue:2 Volume:6 Page:109-113
ISSN:2040-2066
Container-title:Antiviral Chemistry and Chemotherapy
language:en
Short-container-title:Antivir Chem Chemother

Author:

Madren L. K.¹,Shipman C.²,Hayden F. G.³

Affiliation:

1. Departments of Internal Medicine and Pathology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA

2. Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI48109, USA

3. Department of Medicine and Pathology, University of Virginia Health Sciences Center, Box 473, Charlottesville, VA 22908, USA

Abstract

To assess the possible interactions among candidate anti-influenza agents, dual combinations of rimantadine, ribavirin, 2′-deoxy-2′-fluoroguanosine (2-FDG) and 4-guanidino-Neu5Ac2en (GG167) were tested against clinical isolates of influenza A H3N2 and H1N1 subtype viruses in MDCK cells by ELISA. Each of the dual combinations showed additive effects, except for the combination of 2-FDG and ribavirin which was synergistic against the influenza A (H1N1) virus. However, this combination also showed enhanced cytotoxicity. In this assay system, influenza agents with differing mechanisms of antiviral interaction interacted in an additive fashion with respect to inhibition of viral replication.

Publisher

SAGE Publications

Link

http://journals.sagepub.com/doi/pdf/10.1177/095632029500600205

Reference22 articles.

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3. Inhibition of Influenza Virus Ribonucleic Acid Polymerase by Ribavirin Triphosphate

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5. Enhancement of activity against influenza viruses by combinations of antiviral agents

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