The Enzymatic Synthesis and Anti-HIV-1 Activity of 9-β-D-2′,3′-Dideoxynucleosides of N(6)-Substituted Purines-Reference-Cited by-同舟云学术

The Enzymatic Synthesis and Anti-HIV-1 Activity of 9-β-D-2′,3′-Dideoxynucleosides of N(6)-Substituted Purines

Published:1990-08 Issue:4 Volume:1 Page:249-253
ISSN:2040-2066
Container-title:Antiviral Chemistry and Chemotherapy
language:en
Short-container-title:Antivir Chem Chemother

Author:

Betbeder D.,Hutchinson D. W.,Richards A. O'L.,Mahood N.¹,Kinchington D.²

Affiliation:

1. Medical Research Council Collaborative Centre, 1-3 Burtonhole Lane, Mill Hill, London NW7 1AD

2. Division of Virology, Department of Medical Microbiology, St Mary's Hospital Medical School, Norfolk Place, London WC2 1PG, UK

Abstract

9-β-D-2′,3′-dideoxyribonucleosides of four N(6)-substituted purines and 1-deazapurine were prepared using crude nucleoside N-deoxyribosyltransferases (EC 2.4.2.6) from Lactobacillus leichmannii. The 2′,3′-dideoxynucleosides derived from N(6)-substituted purines (1–4) are inhibitors of the replication of human immunodeficiency virus type 1 (HIV-1), with EC90 values in the range 20–100 and 20–200 μm, depending on the cell line used, and have low in vitro toxicity at their effective concentrations.

Publisher

SAGE Publications

Link

http://journals.sagepub.com/doi/pdf/10.1177/095632029000100404

Reference15 articles.

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3. The Enzymatic Synthesis of Imidazole Deoxynucleosides: 1-β-D-2′-Deoxyribofuranosyl-5-aminoiinidazole-4-carboxamide and 1-β-D-2′-Deoxyribofuranosylbenzimidazole

4. The stereoselective enzymatic synthesis of 9-β-d-2′-deoxyribofuranosyl 1-deazapurine

5. Synthesis of 2′,3′-dideoxynucleosides by enzymatic trans-glycosylation

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