Antiviral Activity of N4-Aminocytidine Derivatives Related to AZT-Reference-Cited by-同舟云学术

Antiviral Activity of N4-Aminocytidine Derivatives Related to AZT

Published:1995-02 Issue:1 Volume:6 Page:9-16
ISSN:2040-2066
Container-title:Antiviral Chemistry and Chemotherapy
language:en
Short-container-title:Antivir Chem Chemother

Author:

Loakes D.¹,Brown D. M.¹,Mahmood N.²,Balzarini J.³,De Clercq E.³

Affiliation:

1. Medical Research Council, Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK

2. Medical Research Council Collaborative Centre, 1-3 Burtonhole Lane, London NW7 1AD, UK

3. Katholieke Universiteit Leuven, Rega Institute, Minderbroedersstraat 10, B-3000 Leuven, Belgium

Abstract

A number of N4-hydroxy and N4-amino derivatives of 3′-azido-2′,3′-dideoxy-5-methylcytidine have been synthesized and tested for antiviral activity against HIV-1 and HIV-2. The N4-phenylamino and N4-dimethylamino analogues show marked anti-HIV activity which is comparable to that of AZT.

Publisher

SAGE Publications

Link

http://journals.sagepub.com/doi/pdf/10.1177/095632029500600102

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