The Inhibitory Activity of Diazinyl-Substituted Thiourea Derivatives on Human Immunodeficiency Virus Type 1 Reverse Transcriptase-Reference-Cited by-同舟云学术

The Inhibitory Activity of Diazinyl-Substituted Thiourea Derivatives on Human Immunodeficiency Virus Type 1 Reverse Transcriptase

Published:1997-10 Issue:5 Volume:8 Page:443-446
ISSN:2040-2066
Container-title:Antiviral Chemistry and Chemotherapy
language:en
Short-container-title:Antivir Chem Chemother

Author:

Heinisch G¹,Matuszczak B¹,Pachler S¹,Rakowitz D¹

Affiliation:

1. Institute of Pharmaceutical Chemistry, University of Innsbruck, Innrain 52a, A-6020 Innsbruck, Austria

Abstract

Starting from 2-(2-aminoethyl)pyridine, a series of N-diazinyl-N′-[2-(2-pyridyl)ethyl]thioureas was prepared via the (2-pyridyl)ethylisothiocyanate and was screened as non-nucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitors. Derivatives bearing a 3-pyridazinyl or a 4-pyrimidinyl moiety turned out to be the most potent compounds. However, they exhibited less activity than nevirapine or trovirdine.

Publisher

SAGE Publications

Link

http://journals.sagepub.com/doi/pdf/10.1177/095632029700800507

Reference7 articles.

1. Phenethylthiazolethiourea (PETT) Compounds, a New Class of HIV-1 Reverse Transcriptase Inhibitors. 1. Synthesis and Basic Structure-Activity Relationship Studies of PETT Analogs

2. Non-nucleoside reverse transcriptase inhibitors (NNRTIs)

3. Antiviral therapy for human immunodeficiency virus infections

4. Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 1. Tricyclic pyridobenzo- and dipyridodiazepinones

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