Clozapine-induced type-2 diabetes mellitus: possible mechanisms and implications for clinical practice-Reference-Cited by-同舟云学术

Clozapine-induced type-2 diabetes mellitus: possible mechanisms and implications for clinical practice

Published:2005-03 Issue:2 Volume:19 Page:207-210
ISSN:0269-8811
Container-title:Journal of Psychopharmacology
language:en
Short-container-title:J Psychopharmacol

Author:

Tovey Elizabeth¹,Rampes Hagen²,Livingstone Callum³

Affiliation:

1. West London Mental Health NHS Trust, John Conolly Wing, Middlesex, UK

2. Barnet, Enfield and Haringey Mental Health NHS Trust, North West Community Mental Health Team, Edgware, Middlesex, UK,

3. Clinical Biochemistry Department, Royal Surrey County Hospital, Guildford, Surrey, UK

Abstract

The atypical antipsychotic clozapine has been reported to be associated with metabolic adverse effects, including type-2 diabetes mellitus. We present two cases of diabetes mellitus associated with clozapine treatment. One case resolved entirely upon withdrawal of the drug, whereas the other did not. We discuss the molecular basis of the diabetogenic action of clozapine and recommendations for monitoring.

Publisher

SAGE Publications

Subject

Pharmacology (medical),Psychiatry and Mental health,Pharmacology

Link

http://journals.sagepub.com/doi/pdf/10.1177/0269881105049043

Reference20 articles.

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2. Euglycemic Clamp Study in Clozapine-Induced Diabetic Ketoacidosis

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4. Antipsychotic drugs affect glucose uptake and the expression of glucose transporters in PC12 cells

5. The glucose transporter family: structure, function and tissue-specific expression

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