A multicentre, double-blind, amitriptyline-controlled study of mirtazapine in patients with major depression

Author:

Mullin John1,Lodge Adrian2,Bennie Ernest3,McCreadie Robin4,Bhatt Ganga Singh5,Fenton George6

Affiliation:

1. East Yorkshire Community Healthcare, De la Pole Hospital, Willerby, Hull HU10 6ED

2. Andrew Duncan Clinic, Royal Edinburgh Hospital, Edinburgh

3. Leverndale Hospital, Glasgow

4. Department of Clinical Research, Crichton Royal Hospital, Dumfries

5. Department of Psychological Medicine, Fairfield General Hospital, Bury

6. Department of Psychiatry, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK

Abstract

Background: the efficacy and tolerability of the new antidepressant mirtazapine were evaluated in a multicentre, randomized, double-blind, amitriptyline-controlled, 5 week clinical study. Method: 156 patients with a DSM-III diagnosis of major depressive episode and 21-item Hamilton Psychiatric Rating Scale for Depression (HPRSD) score ≥ 18, were randomized to treatment with either mirtazapine 20-60 mg/day or amitriptyline 75-225 mg/day. Results: mirtazapine and amitriptyline were equally effective in reducing depressive symptoms, as assessed by the 17-item HPRSD and MADRS scales. Mirtazapine was better tolerated than amitriptyline, with fewer drop-outs due to adverse events and lower incidences of adverse events both at the beginning and at the end of the trial. Conclusion: this study shows that mirtazapine is as effective as amitriptyline in treating major depression, while at the same time better tolerated.

Publisher

SAGE Publications

Subject

Pharmacology (medical),Psychiatry and Mental health,Pharmacology

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