Neurotensin: A role in substance use disorder?-Reference-Cited by-同舟云学术

Neurotensin: A role in substance use disorder?

Published:2016-01-11 Issue:2 Volume:30 Page:112-127
ISSN:0269-8811
Container-title:Journal of Psychopharmacology
language:en
Short-container-title:J Psychopharmacol

Author:

Ferraro Luca¹²,Tiozzo Fasiolo Laura¹,Beggiato Sarah³,Borelli Andrea C³,Pomierny-Chamiolo Lucyna⁴,Frankowska Malgorzata⁵,Antonelli Tiziana³,Tomasini Maria C¹,Fuxe Kjell³,Filip Malgorzata⁵

Affiliation:

1. Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy

2. Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy

3. Department of Medical Sciences, University of Ferrara, Ferrara, Italy

4. Department of Toxicology, Medical College, Jagiellonian University, Kraków, Poland

5. Laboratory of Drug Addiction Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland

Abstract

Neurotensin is a tridecapeptide originally identified in extracts of bovine hypothalamus. This peptide has a close anatomical and functional relationship with the mesocorticolimbic and nigrostriatal dopamine system. Neural circuits containing neurotensin were originally proposed to play a role in the mechanism of action of antipsychotic agents. Additionally, neurotensin-containing pathways were demonstrated to mediate some of the rewarding and/or sensitizing properties of drugs of abuse. This review attempts to contribute to the understanding of the role of neurotensin and its receptors in drug abuse. In particular, we will summarize the potential relevance of neurotensin, its related compounds and neurotensin receptors in substance use disorders, with a focus on the preclinical research.

Publisher

SAGE Publications

Subject

Pharmacology (medical),Psychiatry and Mental health,Pharmacology

Link

http://journals.sagepub.com/doi/pdf/10.1177/0269881115622240

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