Three regulatory compliant test systems show no signs of MDMA-related genotoxicity-Reference-Cited by-同舟云学术

Three regulatory compliant test systems show no signs of MDMA-related genotoxicity

Published:2021-08-31 Issue:11 Volume:35 Page:1431-1434
ISSN:0269-8811
Container-title:Journal of Psychopharmacology
language:en
Short-container-title:J Psychopharmacol

Author:

Cohen Isaac Victor¹^ORCID,Barber Laken²³^ORCID,Dubnicka Tyson Paul⁴,Hurtado Sara Beth⁵,Tincher Sarah Ann⁵,Stankowski Leon Frank⁵,Yazar-Klosinski Berra⁶

Affiliation:

1. Clinical Pharmacology and Therapeutics (CPT) Postdoctoral Training Program, University of California San Francisco, San Francisco, CA, USA

2. Division of Biochemistry, Hawai’i Pacific University, Honolulu, Hawaii

3. Safety Department, MAPS Public Benefit Corporation, San Jose, CA, USA

4. Charles River Laboratories, Mattawan, MI, USA

5. Charles River Laboratories, Skokie, IL, USA

6. Executive Department, Multidisciplinary Association for Psychedelic Studies, San Jose, CA, USA

Abstract

3,4 Methylenedioxymethamphetamine (MDMA)-assisted therapy has been recently found to be highly effective for treatment of posttraumatic stress disorder (PTSD). Previous studies have been inconclusive in elucidating potential MDMA genotoxicity. We performed three regulatory compliant studies to investigate the potential of genotoxic effects of MDMA treatment in humans: (1) an in vitro bacterial reverse mutation (Ames) assay, (2) an in vitro chromosome aberration test in Chinese hamster ovary cells, and (3) an in vivo micronucleus study in male Sprague Dawley rats. MDMA was found to not have genotoxic effects in any of the assays at or above clinically relevant concentrations.

Funder

Course of Employment for MAPS and MAPS PBC

Publisher

SAGE Publications

Subject

Pharmacology (medical),Psychiatry and Mental health,Pharmacology

Link

http://journals.sagepub.com/doi/pdf/10.1177/02698811211033603

Reference12 articles.

1. Chronic exposure to MDMA (ecstasy) increases DNA damage in sperm and alters testes histopathology in male rats

2. The In Vivo Rodent Micronucleus Assay

3. DNA fragmentation and oxidative stress in the hippocampal formation: a bridge between 3,4-methylenedioxymethamphetamine (ecstasy) intake and long-lasting behavioral alterations

4. The Bacterial Reverse Mutation Test

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Methylenedioxymethamphetamine;Encyclopedia of Toxicology;2024