Dopamine DRD2/ANKK1 Taq1A and DAT1 VNTR polymorphisms are associated with a cognitive flexibility profile in pathological gamblers

Author:

Fagundo Ana B12,Fernández-Aranda Fernando123,de la Torre Rafael24,Verdejo-García Antonio567,Granero Roser28,Penelo Eva8,Gené Manel3,Barrot Carme3,Sánchez Cristina3,Alvarez-Moya Eva1,Ochoa Cristian1,Aymamí Maria Neus1,Gómez-Peña Mónica1,Menchón Jose M129,Jiménez-Murcia Susana123

Affiliation:

1. Department of Psychiatry, University Hospital of Bellvitge (IDIBELL), Barcelona, Spain

2. CIBER Fisiopatología Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III [Carlos III Health Institute], Barcelona, Spain

3. School of Medicine, University of Barcelona, Barcelona, Spain

4. Neuroscience Research Program, ‘Del Mar’ Hospital Medical Research Institute (IMIM), Barcelona, Spain

5. School of Psychology and Psychiatry, Monash University, Melbourne, VIC, Australia

6. Institute of Neuroscience and Department of Clinical Psychology, University of Granada, Granada, Spain

7. Red de Trastornos Adictivos [Network for Addictive Diseases], Instituto de Salud Carlos III, Madrid, Spain

8. Department of Psychobiology and Methodology, Autonomous University of Barcelona, Barcelona, Spain

9. CIBER Salud Mental (CIBERsam), Instituto Salud Carlos III, Barcelona, Spain

Abstract

Like drug addiction, pathological gambling (PG) has been associated with impairments in executive functions and alterations in dopaminergic functioning; however, the role of dopamine (DA) in the executive profile of PG remains unclear. The aim of this study was to identify whether the DRD2/ANKK1 Taq1A-rs1800497 and the DAT1-40 bp VNTR polymorphisms are associated with cognitive flexibility (measured by Wisconsin Card Sorting Test (WCST) and Trail Making Test (TMT)) and inhibition response (measured by Stroop Color and Word Test (SCWT)), in a clinical sample of 69 PG patients. Our results showed an association between DA functioning and cognitive flexibility performance. The Taq1A A1+ (A1A2/A1A1) genotype was associated with poorer TMT performance ( p < 0.05), while DAT1 9-repeat homozygotes displayed better WCST performance ( p < 0.05) than either 10-repeat homozygotes or heterozygotes. We did not find any association between the DRD2 or DAT1 polymorphisms and the inhibition response. These results suggested that pathological gamblers with genetic predispositions toward lower availability of DA and D2 receptor density are at a higher risk of cognitive flexibility difficulties. Future studies should aim to shed more light on the genetic mechanisms underlying the executive profile in PG.

Publisher

SAGE Publications

Subject

Pharmacology (medical),Psychiatry and Mental health,Pharmacology

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