Clonidine-induced changes in the spectral distribution of heart rate variability correlate with performance on a test of sustained attention-Reference-Cited by-同舟云学术

Clonidine-induced changes in the spectral distribution of heart rate variability correlate with performance on a test of sustained attention

Published:1994-01 Issue:1 Volume:8 Page:1-7
ISSN:0269-8811
Container-title:Journal of Psychopharmacology
language:en
Short-container-title:J Psychopharmacol

Author:

Middleton H.C.¹,Coull J.T.²,Sahakian B.J.²,Robbins T.W.²

Affiliation:

1. University of Cambridge Department of Psychiatry, Addenbrooke's Hospital, Hills Rd., Cambridge CB2 2QQ

2. University of Cambridge Department of Experimental Psychology, Downing St., Cambridge CB2 3EB, UK

Abstract

Conventional measures of cardiovascular activity correlate poorly with psychological variables and therefore provide imperfect physiological indices of arousal. We have investigated the effects of clonidine upon the spectral distribution of heart rate variability and upon performance on a test of sustained attention. Our findings suggest that activity of the central noradrenergic system influences the distribution of heart rate variability in the ~ 0.1 Hz range. Furthermore, the finding of a strong correlation between the effects of clonidine upon each of these variables supports the use of spectral analysis of heart rate variability in the study of arousal.

Publisher

SAGE Publications

Subject

Pharmacology (medical),Psychiatry and Mental health,Pharmacology

Link

http://journals.sagepub.com/doi/pdf/10.1177/026988119400800101

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