Brain iron content and cognitive function in patients with β-thalassemia

Author:

Bu Meiru1ORCID,Deng Xi1,Zhang Yu1,Chen Sean W.2,Jiang Muliang3,Chen Bihong T.4

Affiliation:

1. Department of Radiology, First Affiliated Hospital of Guangxi Medical University, Nanning, P. R. China

2. Department of Medical Oncology & Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, CA, USA

3. Department of Radiology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, P. R. China

4. Department of Diagnostic Radiology, City of Hope National Medical Center, Duarte, CA, USA

Abstract

Patients with β-thalassemia (β-TM) may have brain iron overload from long-term blood transfusions, ineffective erythropoiesis, and increased intestinal iron absorption, leading to cognitive impairment. Brain magnetic resonance imaging (MRI) methods such as the transverse relaxation rate, susceptibility-weighted imaging, and quantitative susceptibility mapping can provide quantitative, in vivo measurements of brain iron. This review assessed these MRI methods for brain iron quantification and the measurements for cognitive function in patients with β-TM. We aimed to identify the neural correlates of cognitive impairment, which should help to evaluate therapies for improving cognition and quality of life in patients with β-TM.

Funder

National Natural Science Foundation of China

“Medical Excellence Award” Funded by the Creative Research Development Grant from the First Affiliated Hospital of Guangxi Medical University, P. R. China.

Youth Science Foundation of Guangxi Medical University, P. R. China

Publisher

SAGE Publications

Subject

Hematology

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