Factors mediating cancer risk in systemic lupus erythematosus

Author:

Hardenbergh Dylan1,Molina Emily2ORCID,Naik Rakhi3,Geetha Duvuru4,Chaturvedi Shruti3,Timlin Homa5ORCID

Affiliation:

1. Columbia University Medical Center, New York, NY, USA

2. Johns Hopkins University School of Medicine, Baltimore, MD, USA

3. Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

4. Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

5. Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

Abstract

Patients with systemic lupus erythematosus (SLE) are at an elevated risk for certain cancers compared to the population at large. Cancers seen at higher rates in the SLE population include hematologic malignancies, such as non-Hodgkin lymphoma, and cancers of the lung and thyroid. SLE patients also have a decreased risk for certain malignancies, such as breast cancer, melanoma, and prostate cancer. We review the literature on risk factors for malignancy in patients with SLE and discuss the exogenous and innate factors that are thought to contribute to the unique pattern of cancer risk observed in this patient population. These risk factors are important for providers of SLE patients to understand in order to maintain high clinical suspicion and detect malignancy as soon as possible. Further research is needed to determine the most effective guidelines on counseling patients on cancer screening and prevention.

Publisher

SAGE Publications

Subject

Rheumatology

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