Adult systemic lupus erythematosus in Egypt: The nation-wide spectrum of 3661 patients and world-wide standpoint-Reference-Cited by-同舟云学术

Adult systemic lupus erythematosus in Egypt: The nation-wide spectrum of 3661 patients and world-wide standpoint

Published:2021-05-06 Issue: Volume: Page:096120332110142
ISSN:0961-2033
Container-title:Lupus
language:en
Short-container-title:Lupus

Author:

Gheita Tamer A¹^ORCID,Noor Rasha Abdel²^ORCID,Abualfadl Esam³⁴,Abousehly Osama S³,El-Gazzar Iman I¹,El Shereef Rawhya R⁵,Senara Soha⁶,Abdalla Ahmed M⁷,Khalil Noha M⁸,ElSaman Ahmed M³,Tharwat Samar⁹,Nasef Samah I¹⁰,Mohamed Eman F¹¹^ORCID,Noshy Nermeen¹²,El-Essawi Dina F¹³,Moshrif Abdel Hafeez¹⁴,Fawzy Rasha M¹⁵,El-Najjar Amany R¹⁶,Hammam Nevin¹⁷¹⁸,Ismail Faten⁵,ElKhalifa Marwa¹⁹^ORCID,Samy Nermeen¹²,Hassan Eman¹⁹,Abaza Nouran M²⁰,ElShebini Emad²¹,Fathi Hanan M⁶,Salem Mohamed N²²,Abdel-Fattah Yousra H²³,Saad Ehab²⁴,Abd Elazim Mervat I²⁵,Eesa Nahla N¹,El-Bahnasawy Amany S²⁶,El-Hammady Dina H²⁷,El-Shanawany Amira T²⁸,Ibrahim Soha E²⁰,Said Emtethal A¹⁵,El-Saadany Hanan M²⁹,Selim Zahraa I¹⁷,Fawzy Samar M¹,Raafat Hala A¹

Affiliation:

1. Rheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt

2. Internal Medicine Department, Rheumatology Unit, Tanta University, Gharbia, Egypt

3. Rheumatology Department, Faculty of Medicine, Sohag University, Sohag, Egypt

4. Qena/Luxor Hospitals, Qena, Egypt

5. Rheumatology Department, Faculty of Medicine, Minia University, Minia, Egypt

6. Rheumatology Department, Faculty of Medicine, Fayoum University, Fayoum, Egypt

7. Rheumatology Department, Faculty of Medicine, Aswan University, Aswan, Egypt

8. Internal Medicine Department, Rheumatology Unit, Faculty of Medicine, Cairo University, Cairo, Egypt

9. Rheumatology Unit, Internal Medicine, Mansoura University, Dakahlia, Egypt

10. Rheumatology Department, Faculty of Medicine, Suez-Canal University, Ismailia, Egypt

11. Internal Medicine Department, Rheumatology Unit, Faculty of Medicine (Girls), Al-Azhar University, Cairo, Egypt

12. Internal Medicine Department, Rheumatology Unit, Faculty of Medicine, Ain-Shams University, Cairo, Egypt

13. Internal Medicine Department, Rheumatology Unit, Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt

14. Rheumatology Department, Faculty of Medicine, Al-Azhar University, Assuit, Egypt

15. Rheumatology Department, Faculty of Medicine, Benha University, Kalubia, Egypt

16. Rheumatology Department, Faculty of Medicine, Zagazig University, Sharkia, Egypt

17. Rheumatology Department, Faculty of Medicine, Assuit University, Assuit, Egypt

18. Rheumatology Department, University of California San Francisco (UCSF), San Francisco, CA, USA

19. Internal Medicine Department, Rheumatology Unit, Faculty of Medicine, Alexandria University, Alexandria, Egypt

20. Rheumatology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

21. Internal Medicine Department, Rheumatology Unit, Menoufiya University, Menoufiya, Egypt

22. Internal Medicine Department, Rheumatology Unit, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt

23. Rheumatology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt

24. Rheumatology Department, Faculty of Medicine, South Valley University, Qena, Egypt

25. Rheumatology Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt

26. Rheumatology Department, Faculty of Medicine, Mansoura University, Dakahlia, Egypt

27. Rheumatology Department, Faculty of Medicine, Helwan University, Cairo, Egypt

28. Rheumatology Department, Faculty of Medicine, Menoufiya University, Menoufiya, Egypt

29. Rheumatology Department, Faculty of Medicine, Tanta University, Gharbia, Egypt

Abstract

Objective The aim of this study was to present the epidemiology, clinical manifestations and treatment pattern of systemic lupus erythematosus (SLE) in Egyptian patients over the country and compare the findings to large cohorts worldwide. Objectives were extended to focus on the age at onset and gender driven influence on the disease characteristics. Patients and method This population-based, multicenter, cross-sectional study included 3661 adult SLE patients from Egyptian rheumatology departments across the nation. Demographic, clinical, and therapeutic data were assessed for all patients. Results The study included 3661 patients; 3296 females and 365 males (9.03:1) and the median age was 30 years (17–79 years), disease duration 4 years (0–75 years) while the median age at disease onset was 25 years (4–75 years). The overall estimated prevalence of adult SLE in Egypt was 6.1/100,000 population (1.2/100,000 males and 11.3/100,000 females).There were 316 (8.6%) juvenile-onset (Jo-SLE) and 3345 adult-onset (Ao-SLE). Age at onset was highest in South and lowest in Cairo (p < 0.0001). Conclusion SLE in Egypt had a wide variety of clinical and immunological manifestations, with some similarities with that in other nations and differences within the same country. The clinical characteristics, autoantibodies and comorbidities are comparable between Ao-SLE and Jo-SLE. The frequency of various clinical and immunological manifestations varied between gender. Additional studies are needed to determine the underlying factors contributing to gender and age of onset differences.

Publisher

SAGE Publications

Subject

Rheumatology

Link

http://journals.sagepub.com/doi/pdf/10.1177/09612033211014253

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