Evidence-based recommendations for the prevention and long-term management of thrombosis in antiphospholipid antibody-positive patients: Report of a Task Force at the 13th International Congress on Antiphospholipid Antibodies

Author:

Ruiz-Irastorza G1,Cuadrado MJ2,Ruiz-Arruza I1,Brey R3,Crowther M4,Derksen R5,Erkan D6,Krilis S7,Machin S8,Pengo V9,Pierangeli S10,Tektonidou M11,Khamashta M2

Affiliation:

1. Autoimmune Disease Research Unit, Department of Internal Medicine, Hospital de Cruces, University of the Basque Country, Barakaldo, Spain

2. Lupus Research Unit, The Rayne Institute, Guy’s, King’s and St Thomas’ School of Medicine, King’s College, London, UK

3. Department of Neurology, University of Texas Health Science Center at San Antonio School of Medicine, USA

4. Division of Hematology and Thromboembolism, McMaster University, Canada

5. Department of Rheumatology and Clinical Immunology, University Medical Centre, Utrecht, The Netherlands

6. The Barbara Volcker Center for Women and Rheumatic Disease, Hospital for Special Surgery, Weill Medical College of Cornell University, New York, USA

7. Department of Immunology, Allergy & Infectious Disease, St George Hospital, University of New South Wales, Australia

8. Department of Haematology, University College London, London, UK

9. Clinical Cardiology, University Hospital, Padova, Italy

10. Antiphospholipid Standardization Laboratory, Division of Rheumatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA

11. First Department of Internal Medicine, Medical School, National University of Athens, Athens, Greece

Abstract

The antiphospholipid syndrome (APS) is defined by the presence of thrombosis and/or pregnancy morbidity in combination with the persistent presence of circulating antiphospholipid antibodies: lupus anticoagulant, anticardiolipin antibodies and/or anti-β2-glycoprotein I antibodies in medium to high titers. The management of thrombosis in patients with APS is a subject of controversy. This set of recommendations is the result of an effort to produce guidelines for therapy within a group of specialist physicians in Cardiology, Neurology, Hematology, Rheumatology and Internal Medicine, with a clinical and research focus on APS.

Publisher

SAGE Publications

Subject

Rheumatology

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