Major Histocompatibility Complex Genes and Susceptibility to Systemic Lupus Erythematosus in Northern India-Reference-Cited by-同舟云学术

Major Histocompatibility Complex Genes and Susceptibility to Systemic Lupus Erythematosus in Northern India

Published:1993-10 Issue:5 Volume:2 Page:313-314
ISSN:0961-2033
Container-title:Lupus
language:en
Short-container-title:Lupus

Author:

Mehra N.K.¹,Pande Ira²,Taneja Veena¹,Uppal S.S.²,Saxena S.P.²,Kumar A.²,Malaviya A.N.²

Affiliation:

1. Histocompatibility and Immunogenetics Unit, All India Institute of Medical Sciences, New Delhi-29, India

2. Clinical Immunology Unit, Department of Medicine, All India Institute of Medical Sciences, New Delhi-29, India

Abstract

Fifty-eight patients with systemic lupus erythematosus (SLE) from Northern India were tissue typed for HLA class I and II antigens. The results revealed an appreciable increase of HLA-DR4 (37.5%) among patients compared with controls (17.9%), P < 0.03. Additionally, haplotype B8-DR3 was encountered frequently in the patient group. The findings suggest an important role of MHC genes in influencing susceptibility to SLE.

Publisher

SAGE Publications

Subject

Rheumatology

Link

http://journals.sagepub.com/doi/pdf/10.1177/096120339300200506

Reference22 articles.

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