Fingerprinting of anti-citrullinated protein antibodies (ACPA): specificity, isotypes and subclasses

Author:

Pratesi F1,Panza F1,Paolini I2,Petrelli F1,Puxeddu I1,Casigliani-Rabl S1,Ancillotti D1,Alcaro C2,Rovero P23,Migliorini P12

Affiliation:

1. Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

2. Toscana Biomarkers Spa, Siena, Italy

3. Department of Pharmacological Sciences, University of Florence, Florence, Italy

Abstract

Anti-citrullinated protein antibodies (ACPA) are a family of rheumatoid arthritis (RA)-specific autoantibodies that recognize the amino acid citrulline, resulting from the post-translational modification of arginine. Peptidyl arginine deiminase, the enzyme responsible for citrullination, is present in humans in different isoforms with different tissue distribution, enzymatic activity and target specificity; nonetheless, the number of proteins citrullinated in physiological or pathological conditions is wide, but not every citrullinated protein is a target for antibodies. In pre-RA patients the immune response to citrullinated antigens is initially restricted, expands with time and, after the onset of the disease, is relatively stable. ACPA are heterogeneous in terms of not only fine specificity but also isotype and IgG subclasses usage. This heterogeneity may be relevant for the immunopathogenesis of RA, conditioning the interaction of antibodies with complement and Fc receptors.

Publisher

SAGE Publications

Subject

Rheumatology

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