Serum soluble markers of immune activation and disease activity in systemic lupus erythematosus

Author:

Samsonov Mikhail Y1,Tilz Gernot P2,Egorova Olga3,Reibnegger Gilbert4,Balabanova Rimma M3,Nassonov Eugeney L1,Nassonova Valentina A3,Wachter Helmut4,Fuchs Dietmar4

Affiliation:

1. Laboratory of Clinical Immunology, Cardiology Research Center, Moscow, Russia

2. Department of Internal Medicine, University of Graz, Graz, Austria

3. Institute of Rheumatology, Russian Medical Academia, Moscow, Russia

4. Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Innsbruck, Fritz-Pregl-Str. 3, A-6020 Innsbruck, Austria

Abstract

We investigated a possible association between markers of immune activation and disease activity in 52 patients with systemic lupus erythematosus (SLE). Serum concentrations of neopterin, beta- 2-microglobulin, 55 kD-type soluble tumor necrosis factor receptor, soluble interleukin-2 receptor and soluble CD8 were compared to the Index of European Consensus Lupus Activity Measurement (ECLAM). All markers of immune activation, except sCD8, significantly correlated with ECLAM. Stepwise multiple linear regression analysis revealed erythrocyte sedimentation rate and neopterin to correlate best with ECLAM (multiple correlation coefficient = 0.74, P < 0.001). The study shows that serum neopterin concentrations are a useful independent index for disease activity in SLE. The finding of enhanced concentrations of various parameters of immune activation in patients confirm a role of the T cell and macrophage activation in the pathogenesis of SLE.

Publisher

SAGE Publications

Subject

Rheumatology

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