Avidity of anti-β2-glycoprotein I antibodies in patients with antiphospholipid syndrome-Reference-Cited by-同舟云学术

Avidity of anti-β2-glycoprotein I antibodies in patients with antiphospholipid syndrome

Published:2012-05-25 Issue:7 Volume:21 Page:764-765
ISSN:0961-2033
Container-title:Lupus
language:en
Short-container-title:Lupus

Author:

Čučnik S¹,Kveder T¹,Artenjak A¹,Gallova Z Ulcova²,Swadzba J³,Musial J³,Iwaniec T³,Stojanovich L⁴,Alessandri C⁵,Valesini G⁵,Avčin T⁶,Tervaert JW Cohen⁷,Rozman B¹,Božič B¹⁸

Affiliation:

1. University Medical Centre, Department of Rheumatology, Ljubljana, Slovenia

2. Charles University, Medical School, Department of Gynecology and Obstetrics, Plzen- Lochotin, Czech Republic

3. Jagiellonian University Medical College, Department of Medicine, Krakow, Poland

4. Bezhanijska Kosa, University Medical Centre, Belgrade University, Serbia

5. Sapienza University of Rome, Dipartimento di Medicina Interna e Specialità Mediche, Rome, Italy

6. University Medical Centre, University Children’s Hospital Ljubljana, Department of Allergology, Rheumatology and Clinical Immunology, Ljubljana, Slovenia

7. Maastricht University Medical Center, Division of Clinical and Experimental Immunology, Department of Internal Medicine, Maastricht, the Netherlands

8. University in Ljubljana, Faculty of Pharmacy, Chair for Clinical Biochemistry, Ljubljana, Slovenia

Abstract

Antibodies against β2-glycoprotein I (anti-β2GPI) are one of the hallmarks of the antiphospholipid syndrome (APS). However, they are heterogenic regarding their epitope specificity, pathogenic mechanisms and their avidity. In the current study we present some outstanding issues about avidity of anti-β2GPI antibodies. Our results confirmed that high avidity anti-β2GPI are associated with thrombosis and APS, while in low avidity anti-β2GPI group non-APS (predominantly systemic lupus erythematosus) patients prevailed.

Publisher

SAGE Publications

Subject

Rheumatology

Link

http://journals.sagepub.com/doi/pdf/10.1177/0961203312440057

Reference8 articles.

1. Testing for and Clinical Significance of Anticardiolipin Antibodies

2. Avidity of anti-beta-2-glycoprotein I antibodies

3. The avidity of anti-β2-glycoprotein I antibodies in patients with or without antiphospholipid syndrome: a collaborative study in the frame of the European forum on antiphospholipid antibodies

4. High avidity anti- 2-glycoprotein I antibodies in patients with antiphospholipid syndrome

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