Alexithymia in systemic lupus erythematosus: A cross sectional study in a Brazilian sample

Abstract

Background Alexithymia is considered as a reduced capacity to be aware of, to clearly recognize, and to define one’s feelings with a limited fantasy and a concrete, externally oriented cognitive style. Some studies have stated that alexithymia is more common in systemic lupus erythematosus patients (SLE) than in general population but there is a paucity of studies in such context. Aim To study the prevalence of alexithymia in a sample of SLE patients looking for associated epidemiological and clinical findings and its relationship to quality of life. Methods Cross-sectional study in 93 SLE patients collecting clinical, epidemiological, and serological data, data on quality of life by 12 item short health survey (SF-12), and alexithymia by Toronto scale (TAS-26). Disease’s cumulative damage was measured by Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage index. Results In this sample (90.3% females and median age of 46 years), 55.9% had alexithymia; 22/92 (23.9%) did not and 19/93 (20.4%) had inconclusive results. Alexithymia presence had a positive association with age ( p = 0.01) and a negative association with presence of glomerulonephritis (25% vs 59%; p = 0.005) and glucocorticoid use (19.2% vs 59.0%; p = 0.0007). A negative correlation of TAS-26 was observed with mental domain of ( r = −0.46; p < 0.0001) and physical domain ( r = −0.32; p = 0.004) of SF-12, but not with cumulative damage index. Conclusion We found a high prevalence of alexithymia in this sample of SLE patients that negatively associated with quality of life, but not with cumulative damage index.