1. Department of Rheumatology, University of Birmingham, UK
2. Department of Clinical Pharmacology, University of Birmingham, UK
3. Department of Paediatrics, University of Birmingham, UK
4. Warwick Clinical Trials Unit, University of Warwick, UK
5. Department of Cardiology, University of Birmingham, UK
6. Department of Rheumatology, Division of Immunity and Infection, University of Birmingham, Birmingham B15 2TT, UK;