Lupus and T Cells-Reference-Cited by-同舟云学术

Lupus and T Cells

Published:2009-03 Issue:3 Volume:18 Page:196-201
ISSN:0961-2033
Container-title:Lupus
language:en
Short-container-title:Lupus

Author:

La Cava A¹

Affiliation:

1. Division of Rheumatology, Department of Medicine, University of California, Los Angeles, California, USA

Abstract

T-cell abnormalities and aberrant T helper cytokine profiles have been implicated in the loss of immune tolerance to nuclear and cytoplasmic antigens and linked to a variety of clinical manifestations in systemic lupus erythematosus (SLE). Here, we review the role of T cells in promoting and maintaining SLE in relation to their cellular and molecular abnormalities and provide an update on recent T cell-targeted therapeutic approaches for the restoration of T cell homeostasis in the disease.

Publisher

SAGE Publications

Subject

Rheumatology

Link

http://journals.sagepub.com/doi/pdf/10.1177/0961203308098191

Reference68 articles.

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2. Induction of a cationic shift in IgG anti-DNA autoantibodies. Role of T helper cells with classical and novel phenotypes in three murine models of lupus nephritis.

3. The contribution of L3T4+ T cells to lymphoproliferation and autoantibody production in MRL-lpr/lpr mice.

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