Hematological malignancies in connective tissue diseases

Author:

Noureldine H A1ORCID,Nour-Eldine W1,Hodroj M H2,Noureldine M H A3,Taher A4,Uthman I5

Affiliation:

1. Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Byblos, Lebanon

2. Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon

3. Johns Hopkins University School of Medicine, Institute for Brain Protection Sciences, Johns Hopkins All Children's Hospital, Saint Petersburg, USA

4. Division of Hematology and Medical Oncology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon

5. Division of Rheumatology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon

Abstract

Chronic inflammation has profound tumor-promoting effects. Inflammatory cells are the key players in immunosurveillance against tumors, and immunosuppression is known to increase the risk of tumors. Autoimmune diseases, which manifest as loss of self-tolerance and chronic immune dysregulation, provide a perfect environment for tumor development. Aside from managing the direct inflammatory consequences of autoimmune pathogenesis, cancer risk profiles should be considered as a part of a patient's treatment. In this review, we describe the various associations of malignancies with autoimmune diseases, specifically systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, and Sjögren's syndrome, as well as discuss the mechanisms contributing to the pathogenesis of both disorders.

Publisher

SAGE Publications

Subject

Rheumatology

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