Quality of life in systemic lupus erythematosus: description in a cohort of French patients and association with blood hydroxychloroquine levels-Reference-Cited by-同舟云学术

Quality of life in systemic lupus erythematosus: description in a cohort of French patients and association with blood hydroxychloroquine levels

Published:2016-02-13 Issue:7 Volume:25 Page:735-740
ISSN:0961-2033
Container-title:Lupus
language:en
Short-container-title:Lupus

Author:

Jolly M¹,Galicier L²,Aumaître O³,Francès C⁴,Le Guern V⁵,Lioté F⁶,Smail A⁷,Limal N⁸,Perard L⁹,Desmurs-Clavel H⁹,Boutin D L T H¹⁰,Asli B²,Kahn J-E¹¹,Pourrat J¹²,Sailler L¹³,Ackermann F¹¹,Papo T¹⁴,Sacré K¹⁴,Fain O¹⁵,Stirnemann J¹⁶,Cacoub P¹⁷,Jallouli M⁵,Leroux G¹⁰,Cohen-Bittan J¹⁸,Hulot J-S¹⁹,Arora S¹,Amoura Z¹⁰,Piette J-C¹⁰,Costedoat-Chalumeau N⁵,

Affiliation:

1. Rush University Medical Center, Chicago, IL, USA

2. Université Paris Diderot, Sorbonne Paris-Cité and AP-HP, Hôpital Saint Louis, service d’immunologie clinique, Paris, France

3. Université de Clermont-Ferrand and CHU Clermont-Ferrand, Hôpital Gabriel Montpied, service de médecine interne, Clermont-Ferrand, France

4. UPMC, Université Paris 6 and AP-HP, Hôpital Tenon, service de dermatologie allergologie, Paris, France

5. Université Paris-Decartes and AP-HP, Hôpital Cochin, service de médecine interne, Paris, France

6. Université Paris-Diderot, Sorbonne Paris-Cité and AP-HP, Hôpital Lariboisière, service de rhumatologie, Paris, France

7. CHU Amiens, Hôpital Nord, service de médecine interne, Amiens, France

8. UPEC; AP-HP, Hôpital Henri Mondor, service de médecine interne, Créteil, France

9. Hospices Civils de Lyon, Groupement Hospitalier Edouard Herriot, service de médecine interne, Lyon, France

10. UPMC, Université Paris 6 and AP-HP, Hôpital Pitié-Salpêtrière, service de médecine interne, Paris, France

11. Hôpital Foch, service de médecine interne, Suresnes, France

12. Université Paul-Sabatier and CHU Toulouse, Hôpital Rangueil, service de néphrologie, Toulouse, France

13. Université Paul-Sabatier and CHU Toulouse, Hôpital Purpan, service de médecine interne, Toulouse, France

14. Université Paris-Diderot, Sorbonne Paris-Cité and AP-HP, Hôpital Bichat Claude-Bernard, service de médecine interne, Paris, France

15. Hôpital Saint Antoine, DHU i2B, service de médecine interne, Université Paris 6

16. Division of General Internal Medicine, Geneva University Hospital, Geneva, Switzerland

17. APHP, Département de Médecine Interne et Immunologie clinique, Groupe Hospitalier Pitié Salpétriére Paris, France; DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, Paris VI, France; UMR 7211 (UPMC/CNRS), UMR S-959 (INSERM)

18. UPMC, Université Paris 6 and AP-HP, Hôpital Pitié-Salpêtrière, service de gériatrie Pr Verny, Paris, France

19. Sorbonne Universités, UPMC Univ Paris 06, AP-HP, Institute of Cardiometabolism and Nutrition (ICAN), F-75013, Paris, France

Abstract

Objectives Benefits of hydroxychloroquine (HCQ) use on physician reported outcomes are well documented in systemic lupus erythematosus (SLE). We assess for the first time the association and predictive value of blood HCQ levels towards health-related quality of life (HRQOL) in SLE. Methods Data from the PLUS study (a randomized, double-blind, placebo-controlled, multicentre study) were utilized. Blood HCQ levels were quantified by high-performance liquid chromatography along with HRQOL assessments (Medical Outcomes Study-SF-36) at baseline (V1) and month 7 (V2). Results 166 SLE patients’ data were analysed. Mean (SD) age and disease duration were 44.4 (10.7) and 9.3 (6.8) years. Eighty-seven per cent were women. Mean (SD, median, IQR) HCQ concentrations in the blood at V1 were 660 (314, 615, 424) ng/ml and increased to 1020 (632, 906, 781) ng/ml at V2 (mean difference 366 units, 95% confidence interval −472 to −260, p < 0.001). No significant correlations between HCQ concentrations with HRQOL domains at V1 or V2 were noted. There were no differences in HRQOL stratified by HCQ concentrations. HCQ concentrations at V1 or changes in HCQ concentration (V2-V1) were not predictive of HRQOL at V2 or changes in HRQOL (V2-V1). Conclusions No association of HCQ concentrations with current or longitudinal HRQOL were found in SLE.

Publisher

SAGE Publications

Subject

Rheumatology

Link

http://journals.sagepub.com/doi/pdf/10.1177/0961203315627200

Reference25 articles.

1. Clinical efficacy and side effects of antimalarials in systemic lupus erythematosus: a systematic review

2. Effect of hydroxychloroquine on the survival of patients with systemic lupus erythematosus: data from LUMINA, a multiethnic US cohort (LUMINA L)

3. Antimalarial treatment may have a time-dependent effect on lupus survival: Data from a multinational Latin American inception cohort

4. Hydroxychloroquine concentration-response relationships in patients with rheumatoid arthritis

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