Phage Display Screen for Peptides That Bind Bcl-2 Protein-Reference-Cited by-同舟云学术

Phage Display Screen for Peptides That Bind Bcl-2 Protein

Published:2010-12-03 Issue:1 Volume:16 Page:82-89
ISSN:1087-0571
Container-title:Journal of Biomolecular Screening
language:en
Short-container-title:J Biomol Screen

Author:

Park Hye-Yeon¹,Kim Joungmok²,Cho June-Haeng¹,Moon Ji Young¹,Lee Su-Jae¹,Yoon Moon-Young¹

Affiliation:

1. Department of Chemistry, College of Natural Sciences, Hanyang University, Seoul, Korea

2. Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.

Abstract

Bcl-2 family proteins are key regulators of apoptosis associated with human disease, including cancer. Bcl-2 protein has been found to be overexpressed in many cancer cells. Therefore, Bcl-2 protein is a potential diagnostic target for cancer detection. In the present study, the authors have identified several Bcl-2 binding peptides with high affinity (picomolar range) from a 5-round M13 phage display library screening. These peptides can be used to develop novel diagnostic probes or potent inhibitors with diverse polyvalencies.

Publisher

Elsevier BV

Link

http://journals.sagepub.com/doi/pdf/10.1177/1087057110385816

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