Designing Chemical Libraries for Lead Discovery-Reference-Cited by-同舟云学术

Designing Chemical Libraries for Lead Discovery

Published:1996-03 Issue:2 Volume:1 Page:65-73
ISSN:1087-0571
Container-title:Journal of Biomolecular Screening
language:en
Short-container-title:J Biomol Screen

Author:

Ferguson Allan M.¹,Patterson David E.¹,Garr Cheryl D.²,Underiner Ted L.²

Affiliation:

1. Tripos Inc., 1699 S. Hanley Road, St. Louis, Missouri 63144

2. Panlabs Inc., 11804 N. Creek Parkway South, Bothell, Washington 98011

Abstract

The selection of compounds for use in high throughput biological assays is one of the critical factors that dictates the likelihood of detecting exploitable biological properties. In this paper, we present a process designed to deliver molecules that contain chemical functionality of immediate value in a lead discovery program, molecules that are sufficiently different from each other to ensure that redundancy of effort is avoided. The design process has already been implemented and used to add tens of thousands of reaction products to the Optiverse™ library

Publisher

Elsevier BV

Link

http://journals.sagepub.com/doi/pdf/10.1177/108705719600100204

Reference16 articles.

1. A general and expedient method for the solid-phase synthesis of 1,4-benzodiazepine derivatives

2. "Diversomers": an approach to nonpeptide, nonoligomeric chemical diversity.

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