Matrix-Based Activity Pattern Classification as a Novel Method for the Characterization of Enzyme Inhibitors Derived from High-Throughput Screening
Author:
Affiliation:
1. Novartis Institutes for Biomedical Research, Center for Proteomic Chemistry, Cambridge, MA, USA
2. National Center for Advancing Translational Sciences, Bethesda, MD, USA
Abstract
Publisher
Elsevier BV
Link
http://journals.sagepub.com/doi/pdf/10.1177/1087057116667255
Reference24 articles.
1. The discovery of first-in-class drugs: origins and evolution
2. Novel trends in high-throughput screening
3. Mechanistic Basis of Enzyme-Targeted Drugs
4. Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase Inhibition
5. Expanding the chemical diversity of CK2 inhibitors
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1. High-Throughput Mechanism of Inhibition;SLAS DISCOVERY: Advancing the Science of Drug Discovery;2021-01-22
2. Enzyme–Inhibitor Interactions and a Simple, Rapid Method for Determining Inhibition Modality;SLAS DISCOVERY: Advancing the Science of Drug Discovery;2019-02-27
3. ADMETopt: A Web Server for ADMET Optimization in Drug Design via Scaffold Hopping;Journal of Chemical Information and Modeling;2018-09-25
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