AGT M235T polymorphism contributes to risk of preeclampsia: evidence from a meta-analysis

Author:

Ni Shanshan1,Zhang Yanyan1,Deng Yulin2,Gong Yunhui1,Huang Juan1,Bai Yi1,Zhou Rong1

Affiliation:

1. Department of Obstetrics and Gynaecology, West China Second University Hospital, Sichuan University, PR China

2. Chinese Evidence-Based Medicine Centre, Sichuan University, PR China

Abstract

Objective: Preeclampsia a hypertensive disorder of pregnancy that mainly manifests as high blood pressure and proteinuria. Angiotensinogen (AGT) plays important roles in the regulation of blood pressure. The purpose of this study was to investigate the relationship between AGT M235T polymorphism and risk of preeclampsia using a meta-analysis. Methods: In this meta-analysis, 22 studies were selected by searching PubMed, EMBASE, ISI and CNKI databases up to October 2011. Crude odds ratios with corresponding 95% confidence intervals were used to evaluate the association between the AGT M235T polymorphism and risk of preeclampsia. Subgroup analyses were conducted by ethnicity and parity. Results: The TT genotype of the AGT M235T polymorphism was associated with elevated risk of preeclampsia in the overall analysis. In subgroup analysis according to ethnicity, increased risks were also found in Caucasians. After stratification based on parity, the excess risk was found in multigravida. Conclusions: These results showed that the TT genotype may play critical roles in the development of preeclampsia.

Publisher

Hindawi Limited

Subject

Endocrinology,Internal Medicine

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