A pilot study of a nurse-delivered cognitive behavioral therapy intervention (Ziphamandla) for adherence and depression in HIV in South Africa

Author:

Andersen Lena S1,Magidson Jessica F2,O’Cleirigh Conall23,Remmert Jessica E2,Kagee Ashraf4,Leaver Matthew1,Stein Dan J15,Safren Steven A6,Joska John1

Affiliation:

1. University of Cape Town, South Africa

2. Massachusetts General Hospital/ Harvard Medical School, USA

3. Fenway Health, USA

4. Stellenbosch University, South Africa

5. Medical Research Council Unit on Anxiety and Stress Disorders, South Africa

6. University of Miami, USA

Abstract

Depression is prevalent among people living with HIV in South Africa and interferes with adherence to antiretroviral therapy. This study evaluated a nurse-delivered, cognitive behavioral therapy intervention for adherence and depression among antiretroviral therapy users with depression in South Africa ( n = 14). Primary outcomes were depression, antiretroviral therapy adherence, feasibility, and acceptability. Findings support robust improvements in mood through a 3-month follow up. Antiretroviral therapy adherence was maintained during the intervention period. Participant retention supports acceptability; however, modest provider fidelity despite intensive supervision warrants additional attention to feasibility. Future effectiveness research is needed to evaluate this nurse-delivered cognitive behavioral therapy intervention for adherence and depression in this context.

Funder

Wellcome Trust

United States Agency for International Development

National Institute of Mental Health

Publisher

SAGE Publications

Subject

Applied Psychology

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