FK-binding protein 5: Possible relevance to the pathogenesis of metabolic dysfunction and alcohol-associated liver disease

Author:

Ma Jing1,Yang Zhihong1,Gao Hui1,Huda Nazmul1,Jiang Yanchao1,Liangpunsakul Suthat123

Affiliation:

1. Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA

2. Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA

3. Roudebush Veterans Administration Medical Center, Indianapolis, IN, USA

Abstract

The FK506-binding protein (FKBP5) plays significant roles in mediating stress responses by interacting with glucocorticoids, participating in adipogenesis, and influencing various cellular pathways throughout the body. In this review, we described the potential role of FKBP5 in the pathogenesis of two common chronic liver diseases, metabolic dysfunction-associated steatotic liver disease (MASLD), and alcohol-associated liver disease (ALD). We provided an overview of the FK-binding protein family and elucidated their roles in cellular stress responses, metabolic diseases, and adipogenesis. We explored how FKBP5 may mechanistically influence the pathogenesis of MASLD and ALD and provided insights for further investigation into the role of FKBP5 in these two diseases.

Funder

U.S. Department of Veterans Affairs

National Institute on Alcohol Abuse and Alcoholism

Indiana University Research Support Fund Grant

the Central Society for Clinical and Translational Research

The Indiana Clinical and Translational Sciences Institute postdoctoral challenge grant

Dean’s Scholar in Medical Research

Indiana University School of Medicine

Publisher

SAGE Publications

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

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