Clinical differences in symptomology, characteristics, and risk factors in patients with post-acute sequelae of COVID-19: an experience from a tertiary-care academic center

Author:

Munipalli Bala1,Paul Stefan1,Mohabbat Arya2,Siddiqui Habeeba3,Li Zhuo3,Abu Dabrh Abd Moain1

Affiliation:

1. Division of General Internal Medicine, Mayo Clinic Florida, Jacksonville, FL, USA

2. Division of General Internal Medicine, Mayo Clinic Rochester, Rochester, Minnesota, USA

3. Department of Quantitative Health Sciences, Mayo Clinic Florida, Jacksonville, FL, USA

Abstract

Coronavirus disease 2019 (COVID-19) is caused by the novel coronavirus SARS-CoV-2 and has caused significant mortality and morbidity since it was first recognized in Wuhan, China in December 2019. Patients may suffer from a constellation of symptoms termed post-acute sequelae of COVID-19 (PASC) . Here we present findings of a retrospective cohort study describing the prevalence and predicting factors of patient-reported post-acute sequelae of COVID-19 (PASC). Categorical variables were summarized as frequency (percentage) and compared between vaccine status groups using Fisher’s exact test. Continuous variables were reported as median (range) and compared between the groups using Kruskal-Wallis test. All tests were two-sided with p value <0.05 considered statistically significant. Survey data from 132 patients with a median age of 45 years, 68% female, 83% Caucasian/Non-Hispanic. The most frequently reported PASC symptoms include fatigue (84.8%), dyspnea (54.5%), cognitive dysfunction (53%), myalgias (37.1%), lightheadedness or vertigo (36.4%), chest pain (34.8%), palpitations (34.8%), headaches (34.1%), arthralgias (31.8%), and unrefreshing sleep (31.1%). There is mounting evidence that supports higher prevalence of PASC in women, White/Caucasian, and middle-aged individuals. This knowledge can provide guidance to clinical practices to anticipate and support healthcare and self-care needs for patients at higher risk to developing PASC.

Funder

Research Accelerator for Clinicians Engaged in Research

Mayo Clinic General Internal Medicine

Publisher

SAGE Publications

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

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