Cultivating Innovative Pragmatic Cluster-Randomized Registry Trials Embedded in Hemodialysis Care: Workshop Proceedings From 2018

Author:

Lee Elliot J.1ORCID,Patel Aakil1,Acedillo Rey R.23,Bachynski Jovina C.4,Barrett Ian5,Basile Erika6,Battistella Marisa78,Benjamin Derek9,Berry David10,Blake Peter G.211,Chan Patricia12,Bohm Clara J.13,Clemens Kristin K.131415,Cook Charles16,Dember Laura17,Dirk Jade S.1,Dixon Stephanie13,Fowler Elisabeth18,Getchell Leah19,Gholami Nazanine20,Goldstein Cory21,Hahn Emma1,Hogeterp Betty22,Huang Susan2,Hughes Michelle23,Jardine Meg J.24,Kalatharan Shasikara19,Kilburn Shane1,Lacson Eduardo25,Leonard Sean1,Liberty Channing26,Lindsay Craig27,MacRae Jennifer M.28,Manns Braden J.29ORCID,McCallum Janice1130,McIntyre Christopher W.3132,Molnar Amber O.133ORCID,Mustafa Reem A.34,Nesrallah Gihad E.35,Oliver Matthew J.36,Pandes Michael37,Pandeya Sanjay38,Parmar Malvinder S.39,Rabin Elijah Z.40,Riley Johnathan41,Silver Samuel A.42,Sontrop Jessica M.1231,Sood Manish M.143ORCID,Suri Rita S.4445,Tangri Navdeep4647,Tascona Daniel J.1123,Thomas Alison5,Wald Ron536ORCID,Walsh Michael3348,Weijer Charles321,Weir Matthew A.1231,Vorster Hans11,Zimmerman Deborah43,Garg Amit X.12331ORCID

Affiliation:

1. ICES, ON, Canada

2. Division of Nephrology, Department of Medicine, London Health Sciences Centre, ON, Canada

3. Department of Epidemiology and Biostatistics, Western University, London, ON, Canada

4. Halton Healthcare Services, Oakville, ON, Canada

5. St. Michael’s Hospital, Toronto, ON, Canada

6. Office of Human Research Ethics, Western University, London, ON, Canada

7. Department of Pharmacy, University Health Network, Toronto, ON, Canada

8. Leslie Dan Faculty of Pharmacy, University of Toronto, ON, Canada

9. Royal Victoria Regional Health Centre, Barrie, ON, Canada

10. Algoma Regional Renal Program, Sault Area Hospital, Sault Ste. Marie, ON, Canada

11. Ontario Renal Network, Cancer Care Ontario, Toronto, Canada

12. Division of Nephrology, Department of Medicine, Michael Garron Hospital, Toronto, ON, Canada

13. Department of Internal Medicine, Max Rady College of Medicine, University of Manitoba, Winnipeg, Canada

14. Division of Endocrinology and Metabolism, Department of Medicine, Western University, London, ON, Canada

15. St. Joseph’s Health Care London, ON, Canada

16. Transplant Ambassador Program, Grand River Hospital, Kitchener, ON, Canada

17. Renal, Electrolyte and Hypertension Division, Perelman School of Medicine, Philadelphia, PA, USA

18. The Kidney Foundation of Canada, Montreal, QC, Canada

19. Can-SOLVE CKD Network, Vancouver, BC, Canada

20. St. Joseph’s Health Centre, Toronto, ON, Canada

21. Rotman Institute of Philosophy, Western University, London, ON, Canada

22. Lakeridge Health Oshawa, ON, Canada

23. Orillia Soldiers’ Memorial Hospital, ON, Canada

24. Innovation & Kidney Research, The George Institute for Global Health, UNSW Sydney, Newtown, NSW, Australia

25. Tufts Medical Center, Boston, MA, USA

26. The Ottawa Hospital, ON, Canada

27. Scarborough Health Network, Toronto, ON, Canada

28. Division of Nephrology, Department of Medicine, University of Calgary, AB, Canada

29. Department of Medicine, Cumming School of Medicine, University of Calgary, AB, Canada

30. Renal Services, London Health Sciences Centre, ON, Canada

31. Kidney Clinical Research Unit, Lawson Health Research Institute, London, ON, Canada

32. Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada

33. Division of Nephrology, Department of Medicine, McMaster University, Hamilton, ON, Canada

34. Division of Nephrology and Hypertension, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, USA

35. Division of Nephrology, Department of Medicine, Humber River Hospital, Toronto, ON, Canada

36. Division of Nephrology, Department of Medicine, University of Toronto, ON, Canada

37. Mackenzie Health, Richmond Hill, ON, Canada

38. Halton Healthcare, Oakville, ON, Canada

39. Kidney Care Centre, Timmins and District Hospital, ON, Canada

40. Niagara Health System, St. Catharines, ON, Canada

41. Ontario SPOR SUPPORT Unit, Toronto, ON, Canada

42. Division of Nephrology, Kingston Health Sciences Center, Queen’s University, Kingston, ON, Canada

43. Division of Nephrology, Department of Medicine, University of Ottawa, ON, Canada

44. Division of Nephrology, Department of Medicine, McGill University, Montreal, QC, Canada

45. Canadian Nephrology Trials Network, Canada

46. Chronic Disease Innovation Centre, Winnipeg, MB, Canada

47. Department of Internal Medicine, University of Manitoba, Winnipeg, Canada

48. Population Health Research Institute, Hamilton, ON, Canada

Abstract

Hemodialysis is a life-sustaining treatment for persons with kidney failure. However, those on hemodialysis still face a poor quality of life and a short life expectancy. High-quality research evidence from large randomized controlled trials is needed to identify interventions that improve the experiences, outcomes, and health care of persons receiving hemodialysis. With the support of the Canadian Institutes of Health Research and its Strategy for Patient-Oriented Research, the Innovative Clinical Trials in Hemodialysis Centers initiative brought together Canadian and international kidney researchers, patients, health care providers, and health administrators to participate in a workshop held in Toronto, Canada, on June 2 and 3, 2018. The workshop served to increase knowledge and awareness about the conduct of innovative, pragmatic, cluster-randomized registry trials embedded into routine hemodialysis care and provided an opportunity to discuss and build support for new trial ideas. The workshop content included structured presentations, facilitated group discussions, and expert panel feedback. Partnerships and promising trial ideas borne out of the workshop will continue to be developed to support the implementation of future large-scale trials.

Funder

government of ontario

Canadian Institutes of Health Research

ICES Kidney, Dialysis and Transplantation

Publisher

SAGE Publications

Subject

Nephrology

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