Affiliation:
1. U.S. Army Public Health Command, Army Institute of Public Health, Toxicology Portfolio, Aberdeen Proving Ground, Aberdeen, MD, USA
Abstract
3-Nitro-1,2,4-triazol-5-one (NTO), an insensitive explosive, was evaluated to assess potential environmental and human health effects. A 14-day oral toxicity study in Sprague-Dawley rats was conducted with NTO in polyethylene glycol -200 by gavage at doses of 0, 250, 500, 1000, 1500, or 2000 mg/kg-d. Body mass and food consumption decreased in males (2000 mg/kg-d), and testes mass was reduced at doses of 500 mg/kg-d and greater. Based on the findings in the 14-day study, a 90-day study was conducted at doses of 0, 30, 100, 315, or 1000 mg/kg-d NTO. There was no effect on food consumption, body mass, or neurobehavioral parameters. Males in the 315 and 1000 mg/kg-d groups had reduced testes mass with associated tubular degeneration and atrophy. The testicular effects were the most sensitive adverse effect and were used to derive a benchmark dose (BMD) of 70 mg/kg-d with a 10% effect level (BMDL10) of 40 mg/kg-d.
Reference39 articles.
1. Smith MW, Cliff MD. NTO-Based Explosive Formulations: A Technology Review. Weapons Systems Division. Salisbury South Australia 5108 Australia: Weapons Systems Division, DSTO Aeronautical and Maritime Research Laboratory; 1999.
2. Acute Inhalation Toxicity and Blood Absorption of 3-Nitro-1,2,4-Triazol-5-One (NTO) in Rats
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