Safety Assessment of Centella asiatica-Derived Ingredients as Used in Cosmetics

Author:

Johnson Wilbur1,Bergfeld Wilma F.2,Belsito Donald V.2,Hill Ronald A.3,Klaassen Curtis D.2,Liebler Daniel C.3,Marks James G.3,Shank Ronald C.3,Slaga Thomas J.2,Snyder Paul W.2,Gill Lillian J.4,Heldreth Bart5

Affiliation:

1. Cosmetic Ingredient Review Former Senior Scientific Analyst/Writer

2. Expert Panel for Cosmetic Ingredient Safety Member

3. Expert Panel for Cosmetic Ingredient Safety Former Member

4. Cosmetic Ingredient Review Former Director

5. Cosmetic Ingredient Review Executive Director

Abstract

The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of 9 Centella asiatica-derived ingredients, which reportedly function primarily as skin conditioning agents in cosmetic products. The Panel reviewed relevant data relating to the safety of these ingredients. The Panel concluded that Centella Asiatica Extract, Centella Asiatica Callus Culture, Centella Asiatica Flower/Leaf/Stem Extract, Centella Asiatica Leaf Cell Culture Extract, Centella Asiatica Leaf Extract, Centella Asiatica Leaf Water, Centella Asiatica Meristem Cell Culture, Centella Asiatica Meristem Cell Culture Extract, and Centella Asiatica Root Extract are safe in the present practices of use and concentration in cosmetics, as described in this safety assessment, when formulated to be non-sensitizing.

Funder

Personal Care Products Council

Publisher

SAGE Publications

Subject

Toxicology

Reference64 articles.

1. United States Department of Agriculture. Germplasm resources information network. Centella asiatica. http://www.ars-grin.gov4/cgi-bin/npgs/html/tax_search.pl. Last Updated 2015.

2. Gattefossé. Technical data sheet: Vegetol hydrocotyl GR040 Hydro (Centella Asiatica Extract). Unpublished data submitted by the Personal Care Products Council on 3-31-2015. 2010. 1-3.

3. Anonymous. Method of manufacture of centella asiatica extract. Unpublished data submitted by the Personal Care Products Council on 9-19-2014. 2014. 1.

4. Personal Care Products Council. Information on centella asiatica extract. Method of manufacture and composition. Unpublished data submitted by the Personal Care Products Council on 10-31-2014. 2014. 1.

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