Preclinical Safety, Pharmacokinetics, and Pharmacodynamics of Recombinant Human Interleukin-21 in Cynomolgus Macaques (Macaca fascicularis)
Author:
Affiliation:
1. ZymoGenetics, a Bristol-Myers Squibb Company, Preclinical Development, Seattle, WA 98102, USA
2. Northwest PK Solutions, Sultan, WA, USA
3. Amgen, Inc, Seattle, WA, USA
4. Dendreon, Seattle, WA, USA
5. CPTxBio LLC, Woodinville WA, USA
Abstract
Publisher
SAGE Publications
Subject
Toxicology
Link
http://journals.sagepub.com/doi/pdf/10.1177/1091581812449661
Reference34 articles.
1. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function
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3. IL-21 Enhances and Sustains CD8+ T Cell Responses to Achieve Durable Tumor Immunity: Comparative Evaluation of IL-2, IL-15, and IL-21
4. IL-21 Induces the Functional Maturation of Murine NK Cells
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