Safety Assessment of Trialkyl Trimellitates as Used in Cosmetics

Author:

Fiume Monice M.1,Bergfeld Wilma F.2,Belsito Donald V.2,Hill Ronald A.3,Klaassen Curtis D.2,Liebler Daniel C.3,Marks James G.3,Shank Ronald C.3,Slaga Thomas J.2,Snyder Paul W.2,Gill Lillian J.4,Heldreth Bart5

Affiliation:

1. Cosmetic Ingredient Review Senior Director

2. Expert Panel for Cosmetic Ingredient Safety Member

3. Expert Panel for Cosmetic Ingredient Safety Former Member

4. Cosmetic Ingredient Review Former Director

5. Cosmetic Ingredient Review Executive Director

Abstract

The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of 5 trialkyl trimellitates. These ingredients, which are all structurally related as alkyl esters of trimellitic acid, are reported to function in cosmetics as skin conditioning agents; 2 of the ingredients are also reported to function in cosmetics as plasticizers. The Panel reviewed the available data to determine the safety of these ingredients, and concluded that the trialkyl trimellitates are safe in the current practices of use and concentration when formulated to be non-irritating.

Funder

Personal Care Products Council

Publisher

SAGE Publications

Subject

Toxicology

Reference79 articles.

1. Eastman Kodak Company. Absorption and metabolism of [hexyl-2-14C] tri-(2-ethylhexyl)trimellitate in the rat; 1984. Date Accessed 1-20-2015. Available electronically at: https://ntrl.ntis.gov: OTS0206636; OTS0507501.

2. Organisation for Economic Development (OECD). Trimellitic anhydride & trimellitic acid (CAS No. 552-30-7; 528-44-9). https://www.inchem.org/documents/sids/sids/TLANA.pdf. Last Updated 2002. Date Accessed 9-4-2014.

3. Final Report of the Cosmetic Ingredient Review Expert Panel on the Safety Assessment of Dicarboxylic Acids, Salts, and Esters

4. European Chemicals Agency (ECHA). Octan-1-ol (CAS No. 111-87-5; caprylyl alcohol). https://apps.echa.europa.eu/registered/data/dossiers/DISS-9c82fa92-822d-1adc-e044-00144f67d249/DISS-9c82fa92-822d-1adc-e044-00144f67d249_DISS-9c82fa92-822d-1adc-e044-00144f67d249.html. Last Updated 2015. Date Accessed 2-5-0015.

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