Affiliation:
1. Department of Fire Technology Southwest Research Institute P.O. Drawer 28510 San Antonio, Texas 78284
Abstract
Mathematical modeling methods for the intoxication of rats by carbon mon oxide and hydrogen cyanide are extended to accommodate combined at mospheres of these fire gas toxicants. Predictions using the Fractional Effective Dose model for both incapacitation and lethality show no significant differences from animal bioassay data. Use of the model is suggested as a potential substitute for live animal testing for the toxicity of smoke produced from burning materials. The model is further shown to have potential utility in the assessment of toxic hazard tenability limits using analytical data from full-scale fires.
Subject
Mechanical Engineering,Mechanics of Materials,Safety, Risk, Reliability and Quality
Reference9 articles.
1. Modeling of Toxicological Effects of Fire Gases: Ii. Mathematical Modeling of Intoxication of Rats By Carbon Monoxide and Hydrogen Cyanide
2. Smith, P.W. "FAA Studies of the Toxicity of Products of Combustion," Proceedings of the First Conference and Workshop on Fire Casualties , B. M. Halpin, Editor, The Johns Hopkins University, Applied Physics Laboratory, pp. 173-184 (May 28-29, 1975).
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34 articles.
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