Modeling of Toxicological Effects of Fire Gases: Iii. Quantification of Post-Exposure Lethality of Rats From Exposure To HCl Atmospheres

Abstract

This paper, the third in a series of publications on the modeling of tox icological effects of fire gases, addresses the quantification of post-exposure lethality of rats from exposure to hydrogen chloride atmospheres. Experimental L(Ct)50 values for HCl varied from about 80,000 ppm-min (5-minute exposure to 16,000 ppm) to about 170,000 ppm-min (60-minute exposure to 2800 ppm). Rele vant data involving non-human primate exposures are cited, which suggest the comparability of the rat and the primate for the purpose of assessing lethal doses of HCl.