Affiliation:
1. Allegheny County Department of Laboratories 10 County Office Building Pittsburgh, PA 15219
2. Department of Industrial Environmental Health Sciences Graduate School of Public Health University of Pittsburgh Pittsburgh, PA 15261
Abstract
The acute lethality of thermal decomposition products of various polymeric materials was investigated using bioassay procedures and a small scale com bustion apparatus. The concentrations of pertinent fire gases individually and in various combinations and the amount of combusted material needed to cause 50% lethality (LC50) during a planned 30 minute exposure and 10 minute recovery period were determined along with the lethal blood cyanide and car boxyhemoglobin (COHb) concentrations. Also, the results of controlled pure gas experiments with CO, HCN, CO2, or low O2 singly or in combination are used in an attempt to explain their role during intoxication by smoke from a variety of polymeric materials, particularly those containing nitrogen and yielding HCN during thermal decomposition. These data gathered in controlled and combustion experiments using mice are compared to toxicological findings in human fire fatalities in an attempt to establish a threshold value for fatal cyanide concentrations in the blood of fire fatalities.
Subject
Mechanical Engineering,Mechanics of Materials,Safety, Risk, Reliability and Quality
Cited by
45 articles.
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