Intraoperative intravenous versus periarticular injection of glucocorticoids in improving clinical outcomes after total knee arthroplasty: A prospective, randomized and controlled study

Author:

Li Qingtian1ORCID,Fang Guibin1ORCID,Liao Weihong12,Chen Binlong1,Yang Yuhui1,Liao Junxing1,Fu Guangtao1,Ma Yuanchen1,Zheng Qiujian12

Affiliation:

1. Department of Orthopedics, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China

2. The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China

Abstract

Background Glucocorticoids have been widely used in perioperative period for postoperative pain relief after total knee arthroplasty (TKA). However, the optimal administration protocols of glucocorticoids remain controversial. This study aims to compare the efficacy of glucocorticoids between intravenous and periarticular injection on clinical outcomes. Methods A total of 114 patients were randomly assigned to intravenous (IV) group ( n = 57) and periarticular injection (PI) group ( n = 57). The IV group received 10 mg dexamethasone intravenously and the PI group received periarticular injection of 10 mg dexamethasone during the procedure. The clinical outcomes were assessed using visual analogue scale (VAS), knee society score (KSS), range of motion (ROM), knee swelling, inflammation markers and complications after TKA. Results The VAS score during walking at 2nd day postoperatively was lower in the PI group compared with the IV group (2.08 ± 1.45 vs 2.73 ± 1.69, p = .039), and there was no significant difference at the other time points of VAS score in two groups. The inflammation markers, knee swelling, knee ROM and KSS score were not statistically different. Vomiting and other complications occurrence were not significantly different between the two groups. Conclusions Intraoperative periarticular injection of glucocorticoids has similar analgesic effect compared to intravenous in the postoperative period following TKA and may be even more effective on the second postoperative day. In addition, periarticular injection of glucocorticoids does not impose an excess risk or complication on patients.

Funder

Natural Science Foundation of Guangdong Province

Starting fund of National Natural Science Foundation of Guangdong Provincial People’s Hospital

Major Science and Technology Project of Guangdong Province

Guangdong Medical Science and Technology Research Fund, grant number

Scientific Research Project of Guangdong Traditional Chinese Medicine Bureau

Publisher

SAGE Publications

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