Affiliation:
1. College of Pharmacy and Pharmaceutical Sciences, The University of Toledo, Toledo, OH, USA
Abstract
Given medical advancements in global healthcare systems over the past decade, it may be reasonable to assume that the incidence of surgical site infections would have decreased; however, surveillance data indicate that these rates have held constant. Surgical prophylaxis guidelines from the United States and United Kingdom recommend cefazolin, vancomycin and clindamycin in most surgeries for no longer than 24 hours. As a result of medication shortages impacting the global supply chain, surgeons have needed to evaluate alternative perioperative antibiotics, such as doxycycline; however, research into using doxycycline for preventing surgical site infections is limited. The goal of this study is to retrospectively assess doxycycline’s efficacy, safety and role in preventing surgical site infections.
Reference14 articles.
1. Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines
2. American Society of Health-System Pharmacists (ASHP) 2023 Drug Shortage Detail: Clindamycin Phosphate Injection, ASHP Available at: https://www.ashp.org/drug-shortages/current-shortages/drug-shortage-detail.aspx?id=97 [Accessed January 2021]
3. Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017
4. Clinical Practice Guidelines for Antimicrobial Prophylaxis in Surgery
5. Centers for Disease Control and Prevention (CDC) 2021 CDC/NHSN Surveillance Definitions for Specific Types of Infections, National Healthcare Safety Network (NHSN) Available at: https://www.cdc.gov/nhsn/pdfs/pscmanual/17pscnosinfdef_current.pdf [Accessed January 2024]