Effect of Iron and Calcium on Salicylazosulphapyridine Metabolism-Reference-Cited by-同舟云学术

Effect of Iron and Calcium on Salicylazosulphapyridine Metabolism

Published:1973-03 Issue:2 Volume:18 Page:45-50
ISSN:0036-9330
Container-title:Scottish Medical Journal
language:en
Short-container-title:Scott Med J

Author:

Das K. M.¹,Eastwood M. A.¹

Affiliation:

1. Wolfson Gastro-intestinal Laboratories, Gastro-intestinal Unit Western General Hospital, Edinburgh

Abstract

Acute experiments involving a single dose of salicylazosulphapyridine (SASP) were performed in 5 volunteers. The peak serum concentration of SASP was found within 3 to 5 hours whereas for sulphapyridine derived from SASP it occurred at 12 to 24 hours. The addition of ferrous sulphate caused a significant decrease in the serum SASP concentration whereas the addition of calcium gluconate delayed the absorption of SASP without disturbing the degree of absorption. Total sulphapyridine concentration did not show any variation.

Publisher

SAGE Publications

Subject

General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/003693307301800203

Reference11 articles.

1. SULPHASALAZINE AND SALICYLAZOSULPHADIMIDINE IN ULCERATIVE COLITIS

2. Controlled trial of sulphasalazine in the treatment of ulcerative colitis

3. An improved and simplified method of detecting the acetylator phenotype.

4. Clinical and radiologic improvement of regional enteritis and enterocolitis after treatment with salicylazosulfapyridine

5. The osmotic effects of some simple molecules and ions on gastric emptying

Cited by 22 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Bewertung von Wechselwirkungen und Dosierungsempfehlungen von synthetischen DMARDs – Evidenz- und konsensbasierte Empfehlungen auf Basis einer systematischen Literatursuche;Zeitschrift für Rheumatologie;2023-10-13

2. Bewertung von Wechselwirkungen und Dosierungsempfehlungen von synthetischen DMARDs – Evidenz- und konsensbasierte Empfehlungen auf Basis einer systematischen Literatursuche;Zeitschrift für Rheumatologie;2023-01-12

3. Aminosalicylates;Meyler's Side Effects of Drugs;2016

4. An evidence-based assessment of the clinical significance of drug-drug interactions between disease-modifying antirheumatic drugs and non-antirheumatic drugs according to rheumatologists and pharmacists;Clinical Therapeutics;2009-08

5. Effect of Food, Food Constituents and Fluid Volume on the Bioavailability of Sotalol;Acta Pharmacologica et Toxicologica;2009-03-13