Association between C-reactive protein levels and development of post-stroke depression: A systematic review and meta-analysis

Author:

Jiang Guizhen1,Zhou Dajin1,Yan Xiumei1,Zheng Qingbin2,Tang Zhuoqiong3ORCID

Affiliation:

1. Clinical laboratory, the second people's hospital of Lishui, Lishui city, China

2. Clinical laboratory, Ningbo haishu No. 3 Hospital, China

3. Clinical laboratory, Ningbo No. 6 Hospital, China

Abstract

Background and aims Different prospective cohort studies have focused on the C-reactive protein ( ie, a pentameric protein) biomarker as a predictor of post-stroke depression. In this review and meta-analysis, we will attempt to synthesize the evidence for the association between C-reactive protein and the development of post-stroke depression. Methods We systematically searched five academic databases for relevant studies according to the PRISMA guidelines. We evaluate the comparative levels of C-reactive protein in patients with stroke and/without depression, and analyzed the hazard ratio to evaluate the overall risk of C-reactive protein levels in patients with stroke. Results We selected eligible studies with 2534 patients (mean age: 65.2  ±  5.9 years) from the initial 10 926 studies in the databases. Increased C-reactive protein levels (Hedge's g, 0.84) in patients with stroke and depression as compared to patients with stroke without depression. Increased levels of C-reactive protein were associated with the onset of depression (Hazard's ratio, 1.6) in patients with stroke. Conclusion Our findings provide an association of C-reactive protein with the development of post-stroke depression, and present higher levels than patients with stroke without depression. Additionally, our findings support the role of C-reactive protein levels as markers for predicting depression in patients with stroke.

Publisher

SAGE Publications

Subject

General Medicine

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