Essential Oil from the Underground Parts of Laserpitium zernyi: Potential Source of α-Bisabolol and its Antimicrobial Activity-Reference-Cited by-同舟云学术

Essential Oil from the Underground Parts of Laserpitium zernyi: Potential Source of α-Bisabolol and its Antimicrobial Activity

Published:2010-02 Issue:2 Volume:5 Page:1934578X1000500
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Popović Višnja¹,Petrović Silvana¹,Pavlović Milica¹,Milenković Marina²,Couladis Maria³,Tzakou Olga³,Duraki Šemija⁴,Niketić Marjan⁵

Affiliation:

1. Institute of Pharmacognosy, Faculty of Pharmacy, University of Belgrade, V. Stepe 450, 11221 Belgrade, Serbia

2. Institute of Microbiology and Immunology, Faculty of Pharmacy, University of Belgrade, V. Stepe 450, 11221 Belgrade, Serbia

3. Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopoli Zographou, 157 71 Athens, Greece

4. School “Kosta Abrašević”, 13. oktobar 82, 11000 Belgrade, Serbia

5. Natural History Museum, Njegoševa 51, 11000 Belgrade, Serbia

Abstract

The composition and antimicrobial activity of the essential oil from the underground parts (roots and rhizomes) of Laserpitium zernyi Hayek (Apiaceae) were investigated. The pale blue essential oil, obtained by hydrodistillation, was analyzed by GC and GC-MS. Forty-three compounds were identified (94.3% of total oil). The main constituent, beside α-pinene (31.6%) was α-bisabolol (30.9%), so this oil may be a novel potential natural source of this sesquiterpene alcohol. The antimicrobial activity was tested using the microdilution method against Gram (+) bacteria (Staphylococcus aureus, S. epidermidis, Micrococcus luteus, Enterococcus faecalis), Gram (–) bacteria (Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli), and two strains of yeast (Candida albicans). L. zernyi oil showed significant antibacterial activity against S. epidermidis, S. aureus and M. luteus, but lower activities against the other tested strains.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1000500228

Reference26 articles.

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