Auroside, a Xylosyl-sterol, and Patusterol A and B, two Hydroxylated Sterols, from two Soft Corals Eleutherobia aurea and Lobophytum patulum

Author:

Yeffet Dina1,Rudi Amira1,Ketzinel Sharon1,Benayahu Yehuda2,Kashman Yoel1

Affiliation:

1. Department of Chemistry, Tel-Aviv University, Tel Aviv, Israel

2. Department of Zoology, Tel Aviv University, Tel Aviv, Israel

Abstract

A new sterol glycoside, auroside (1) and two new hydroxylated sterols, patusterol A and B (2, 3) have been isolated from the South African soft coral Eleutherobia aurea and from the Kenyan soft coral Lobophytum patulum. The structure elucidation was achieved from extensive 1D- and 2D- NMR and MS data, and in the case of auroside also by chemical reactions. In addition, from Lobophytum patulum, was also isolated a known nitrogen containing compound (Z)-N-[2-(4-hydroxyphenyl)ethyl]-3-methyldodec-2-enamide, and from Eleutherobia aurea several, earlier reported, diterpenoids. Compound 2 was found to be toxic to brine shrimp embryos with an LC50 value of 2.30 μM.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

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