Antifungal Activity of Plumericin and Isoplumericin-Reference-Cited by-同舟云学术

Antifungal Activity of Plumericin and Isoplumericin

Published:2011-11 Issue:11 Volume:6 Page:1934578X1100601
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Singh Dharmendra¹,Sharma Umakant¹,Kumar Parveen¹,Gupta Yogesh K²,Dobhal M. P.²,Singh Sarman¹

Affiliation:

1. Department of Laboratory Medicine, All India Institute of Medical Sciences, New Delhi-110 029, India

2. Department of Chemistry, University of Rajasthan, Jaipur-302 055, India

Abstract

This study evaluated the in vitro antifungal activity of the chloroform extract of Plumeria bicolor and its phytoconstituents plumericin and isoplumericin against Candida species and Cryptococcus neoformans by measuring the Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC). Plumericin's consistently high activity against Candida albicans, C. krusei, C. glabrata, C. tropicalis and Cryptococcus neoformans was more potent than isoplumericin and the standard antifungal drug nystatin suggesting its potential as a drug candidate for candidiasis and cryptococcosis.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1100601101

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