Novel Microbial Transformation of Resibufogenin by Absidia coerules-Reference-Cited by-同舟云学术

Novel Microbial Transformation of Resibufogenin by Absidia coerules

Published:2011-11 Issue:11 Volume:6 Page:1934578X1100601
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Zheng Jian¹,Su Dong-Hai²,Zhang Dong-Sheng³,Xin Xiu-Lan²,Liu Jun-Ying²,Tian Yan²,Wei Qing²,Cui Xun⁴

Affiliation:

1. Division of Chinese Materia Medica & Natural products, National Institute for Control of Pharmaceutical & Biological Products, Beijing 100050, China

2. Biotechnology Application Center, Beijing Vocational College of Electronic Science and Technology, Beijing 100029, China

3. Planning and Design Institute of Forest Products Industry, Beijing 100010, China

4. Department of Qriental pharmacy, Woosuk University, Wanju-gun, Jeonbuk 565-701, Korea

Abstract

Resibufogenin is one of the major active components of the Chinese medicine ChanSu. In this paper, microbial transformation of resibufogenin by Absidia coerules AS 3.3382 was investigated and five metabolites were isolated and identified as 5β-hydroxy-resibufogenin (2), 3-epi-resibufogenin (3), 3α-hydroxy-15-oxo-14αH-bufa-20, 22-dienolide (4), 3α,14α,15β-trihydroxy-bufa-20, 22-dienolide (5) and 3-epi-15β-hydroxy-bufalin (6). Among them, 4-6 are novel compounds, and compound 3 is a major transformed product. The cytotoxicities of the compounds against Bel-7402 and Hela cells were investigated, and our result suggested that 14,15-OH configuration was directly related to the cytotoxicities of bufadienolides.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1100601105

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3. Kalanchosides A−C, New Cytotoxic Bufadienolides from the Aerial Parts of Kalanchoe gracilis

4. QSAR Evaluation of the Ch'an Su and Related Bufadienolides against the Colchicine-Resistant Primary Liver Carcinoma Cell Line PLC/PRF/5

5. Isolation and Structure of a 20,21-Epoxybufenolide Series from “Ch'an Su”