Antiviral Furanosesquiterpenes from Commiphora erythraea-Reference-Cited by-同舟云学术

Antiviral Furanosesquiterpenes from Commiphora erythraea

Published:2012-02 Issue:2 Volume:7 Page:1934578X1200700
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Cenci Elio¹²,Messina Federica³,Rossi Elisabetta¹,Epifano Francesco⁴,Marcotullio Maria Carla³²

Affiliation:

1. Dipartimento di Medicina Sperimentale e Scienze Biochimiche- Sez. Microbiologia, Università degli Studi di Perugia, via del Giochetto, 06122 Perugia, Italy

2. These two authors contributed equally to the work.

3. Dipartimento di Chimica e Tecnologia del Farmaco - Sez. Chimica Organica, Università degli Studi, via del Liceo 1, 06123 Perugia, Italy

4. Dipartimento di Scienza del Farmaco - Università degli Studi di Chieti-Via de’ Vestini 31, 66013 Chieti, Italy

Abstract

The crude methanolic extract obtained from C. erythraea resin was chromatographed on silica gel with solvent of increasing polarity. The extract and fractions were evaluated for cytotoxicity and antiviral activity [parainfluenza type 3 virus (PIV3)] by plaque forming units (PFU) reduction assay using HEp-2 cells (human larynx epidermoid carcinoma cell line). From the active fraction, five compounds were isolated and tested. Only two of these showed anti-PIV3 activity with a selectivity index (SI) of 66.6 and 17.5, respectively. Both the compounds are furanosesquiterpenoids.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1200700201

Reference11 articles.

1. First International Symposium on Influenza and Other Respiratory Viruses: summary and overview

2. Estimates of world-wide distribution of child deaths from acute respiratory infections

3. Myrrh - Commiphora chemistry

4. Chemical Composition of the Essential Oil of Commiphora erythraea

5. Anti-inflammatory, antioxidant and antifungal furanosesquiterpenoids isolated from Commiphora erythraea (Ehrenb.) Engl. resin

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