A Norsesterterpene Peroxide from a Marine Sponge Hippospongia sp-Reference-Cited by-同舟云学术

A Norsesterterpene Peroxide from a Marine Sponge Hippospongia sp

Published:2016-04 Issue:4 Volume:11 Page:1934578X1601100
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Su Ching-Chyuan¹²,Su Huey-Jen³,Liang Kai-Ju⁴⁵,Tsai Su-June⁶,Su Jui-Hsin⁴⁵

Affiliation:

1. Antai Medical Care Cooperation Antai Tian-Sheng Memorial Hospital, Pingtung 928, Taiwan

2. Department of Beauty Science, Meiho University, Pingtung 912, Taiwan.

3. Department of Nursing, Meiho University, Pingtung 912, Taiwan

4. National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan

5. Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan

6. Department of Biotechnology and Department of Post Modern Agriculture, Mingdao University, Chang Hua 523, Taiwan

Abstract

One new norsesterterpene peroxide, rhopaloic acid H (1), along with two known related metabolites 2 and 3, were isolated from a marine sponge Hippospongia sp. The structures of compounds were elucidated by means of IR, MS, and NMR techniques and comparison of the NMR data with those of known analogues. Evaluation of the cytotoxicities revealed that compound 2 exhibited significant cytotoxicity against DLD-1, Molt 4, T47D and K-562 cell lines, with IC50 values of 3.18, 0.69, 2.22 and 1.06 μg/mL, respectively. Moreover, compound 3 also showed significant K562 inhibitory activity, with IC50 value of 3.65 μg/mL.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1601100405

Reference5 articles.

1. Rhopaloic acid A: A novel norsesterterpene from a marine sponge, Rhopaloeides sp., which inhibits gastrulation of starfish embryos

2. Novel norsesterterpenes, which inhibit gastrulation of the starfish embryo, from the marine sponge Rhopaloeides sp.

3. Novel sesterterpenoid and norsesterterpenoid RCE-protease inhibitors isolated from the marine sponge Hippospongia sp.

4. Cytotoxic Sesterterpenoids from a Sponge Hippospongia sp.

5. Cytotoxic Scalarane Sesterterpenoids from a Marine Sponge Hippospongia sp