Design, Synthesis and Cytotoxic Evaluation of 4-Anilinoquinazoline– triazole–AZT Hybrids as Anticancer Agents-Reference-Cited by-同舟云学术

Design, Synthesis and Cytotoxic Evaluation of 4-Anilinoquinazoline– triazole–AZT Hybrids as Anticancer Agents

Published:2018-12 Issue:12 Volume:13 Page:1934578X1801301
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Giang Le Nhat Thuy¹²,Nga Nguyen Thi²,Van Dinh Thuy²,Anh Dang Thi Tuyet¹²,Phuong Hoang Thi¹,Thanh Nguyen Ha¹,Anh Le Thi Tu¹,Trung Vu Quoc³,Van Tuyen Nguyen¹²,Van Kiem Phan²⁴

Affiliation:

1. Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam

2. Graduate University of Science and Technology, VAST, 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam

3. Hanoi National University of Education, 136 Xuan Thuy, Cau Giay, Hanoi, Vietnam

4. Institute of Marine Biochemistry, VAST, 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam

Abstract

A series of 4-anilinoquinazoline–triazole–AZT hybrids were designed and synthesized as anticancer agents. Their cytotoxic potential has been evaluated by means of a micro-dilution assay against three human cancer cell lines (KB, epidermoid carcinoma; HepG2, hepatoma carcinoma; SK-Lu-1, non-small lung cancer). The biological results revealed that compounds 4b and 6d showed good anticancer activities against KB, HepG2, and Lu cell lines (IC50 values ranging from 9 μM to 100 μM). Especially, compounds 4b and 6d exhibited up to 3-fold more potent than reference drugs erlotinib hydrochloride and AZT in term of anti-lung cancer activity.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1801301215

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